Human γδ T Cells and Immune Regulation
نویسندگان
چکیده
منابع مشابه
Human T Cells and Immune Regulation
Human T cells appear to belong to non-classical T cells with both innate and adaptive immune features. V 2V 2 (also termed V 9V 2) T cell subset exists only in primates, and in humans that represents a major T cell subpopulation in the blood. V 2V 2 T cells remain to be the only T cell subpopulation that can recognize a welldefined foreign microbial phosphoantigen. This article reviews the rece...
متن کاملPotential Role of Vδ2+ γδ T Cells in Regulation of Immune Activation in Primary HIV Infection
Although conventional regulatory T cells (Tregs) are sufficient in controlling low residual T-cell activation in ART-treated patients, they are not efficient in controlling exaggerated immune activation associated with high levels of HIV replication in primary HIV infection (PHI). Our previous data suggested that double negative (DN) T cells including mainly γδ DN T cells play a role in the con...
متن کاملRegulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters
1 Department of Pathology, University of Cambridge, Cambridge, United Kingdom, 2 Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom, 3 Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, 4 Institut für Virologie und Immunbiologie, JuliusMaximilians-Universität Würzburg, Würzbur...
متن کاملPathogen-Specific Immune Fingerprints during Acute Infection: The Diagnostic Potential of Human γδ T-Cells
The last 200 years have seen a dramatic reduction in the prevalence and severity of microbial infections, due to the implementation of groundbreaking measures ranging from improved sanitation and hygiene and the introduction of aseptic techniques to the development of successful vaccines and the discovery of effective antibiotics. Devastating infections that were common until the late nineteent...
متن کاملInnate Immune Surveillance of Spontaneous B Cell Lymphomas by Natural Killer Cells and γδ T Cells
Few studies have demonstrated that innate lymphocytes play a major role in preventing spontaneous tumor formation. We evaluated the development of spontaneous tumors in mice lacking beta-2 microglobulin (beta2m; and thus MHC class I, CD1d, and CD16) and/or perforin, since these tumor cells would be expected to activate innate effector cells. Approximately half the cohort of perforin gene-target...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Open Immunology Journal
سال: 2014
ISSN: 1874-2262
DOI: 10.2174/1874226200902010127